The two substances are believed to have very similar pharmacological mechanisms as monoamine reuptake inhibitors. However, they have been reported to display distinctive subjective effects, with 4F-MPH being considered significantly more euphoric and recreational.
Reports suggest that it is more potent with fewer uncomfortable side effects such as anxiety, muscle spasms and compulsive redosing. This perhaps owes to the fact that it has been shown to act as a higher efficiency dopamine reuptake inhibitor. This is in contrast to the parent compound methylphenidate.
4F-MPH has an extremely short history of recreational use and has yet to be documented being sold on the streets. It was initially developed as a replacement for ethylphenidate which became illegal in the United Kingdom on April 2015. This was due to a temporary blanket ban. Shortly after, it became available for sale on the online gray market as a research chemical for global distribution.
4F-MPH is characterized by high potency, long-lasting stimulant effect, likely habit-forming properties as well as unknown toxicity profile. Thus, it is strongly recommended that one use proper harm reduction practices if choosing to use this substance.
Pharmacology of 4F-MPH
4F-MPH is thought to act primarily as a dopamine reuptake inhibitor. Thus, it effectively boosts the levels of dopamine neurotransmitters in the brain. This is done by binding to and partially blocking the transporter proteins that clear these monoamines from the synaptic cleft. This allows dopamine to accumulate within the reward pathways in the brain, resulting in stimulating and euphoric effects.